pulmonary surfactants การใช้

• Pulmonary surfactant increases compliance by decreasing the surface tension of water.
• This role is critical for making pulmonary surfactant ( see below)
• A deficiency of pulmonary surfactant in preterm infants results in respiratory distress syndrome.
• It is a pulmonary surfactant for infants who lack enough natural surfactant in their lungs.
• Pulmonary surfactants are also naturally secreted by type II cells of the lung alveoli in mammals.
• Together with SP-A2 ( see SFTPA2 ), they are the most abundant proteins of pulmonary surfactant.
• Together with SP-A1 ( see SFTPA1 ), they are the most abundant proteins of pulmonary surfactant.
• Insufficient pulmonary surfactant in the alveoli can contribute to atelectasis ( collapse of part or all of the lung ).
• SP-B is a critical protein for lung function, and is found in the context of pulmonary surfactant.
• Reductions in pressure and exposure will be made progressively, and medications such as bronchodilators and pulmonary surfactants may be used.
• In humans, this protein was shown to be localized to the human alveolar type II pneumocytes, which synthesize and secrete pulmonary surfactant.
• The development of pulmonary surfactant, which facilitates the oxygenation and ventilation of underdeveloped lungs, has been the most important development in neonatology to date.
• The major surfactant deficiency in premature infants relates to the lack of phosphatidylglycerol, even though it comprises less than 5 % of pulmonary surfactant phospholipids.
• Phosphatidylcholine is a major constituent of cell membranes and pulmonary surfactant, and is more commonly found in the exoplasmic or outer leaflet of a cell membrane.
• Pulmonary surfactant is a complex system of lipids, proteins and glycoproteins that are produced in specialized lung cells called Type II cells or Type II pneumocytes.
• At the end of the fourth week the lung bud divides into two, the right and left primary type II alveolar cells that secrete pulmonary surfactant, appear.
• Without pulmonary surfactant, atelectasis is a certainty; however, there are other causes of lung collapse such as trauma ( pneumothorax ), COPD, and pleuritis.
• As a Beckman Young Investigator, Allen studied the biophysics of the lung as a barrier mediating oxygen and carbon dioxide transport, and the importance of pulmonary surfactants.
• In the United States National Library of Medicine's Medical Subject Headings ( MeSH ) vocabulary, " surfactant " is reserved for the meaning pulmonary surfactant.
• Other actions include contributing to pulmonary surfactant synthesis of the fetal lungs at the end of the pregnancy and immune tolerance of the fetus by the maternal organism during pregnancy.